MooFlex
// December 18th, 2005 // Technology Bits
MooFlex is a CMS that may be interesting. What interests me primarily is their heavy AJAX usage. If this application is designed well, using modern web technologies, I am intrigued by its long term potential. As we look to find a CMS to convert our University to, we hope to have a great deal of flexibility in what we can accomplish. Some on our team have even gone as far as saying we want to create a Web 2.0 university site. We’ll see how close to that we actually get.
The company responsible for producing this is based in Italy and called mad4milk.
2012 
They seem to be using Prototype for their AJAX stuff but are using their own DOM effects and controls libraries rather than Script.aculo.us.